SCHEMBL6980130

SCHEMBL6980130

Cc1cn2c3ccc(Cl)cc3c3cccc(c1=O)c32

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.44
AURKB Q96GD4 3/20 0.40
PLK4 O00444 2/20 0.40
MAPK8 P45983 2/20 0.40
MAPK9 P45984 2/20 0.40
CLK4 Q9HAZ1 1/20 0.40
SRPK1 Q96SB4 2/20 0.38
AURKA O14965 1/20 0.38
RPS6KA4 O75676 1/20 0.38
MAPKAPK2 P49137 1/20 0.38
GSK3B P49841 1/20 0.38
MARK2 Q7KZI7 1/20 0.38
BRSK1 Q8TDC3 1/20 0.38
PLK3 Q9H4B4 1/20 0.38
GABRA1 P14867 3/20 0.37
GABRG2 P18507 3/20 0.37
GABRB3 P28472 3/20 0.37
GABRA5 P31644 3/20 0.37
KMT2A Q03164 2/20 0.37
MAP4K4 O95819 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6976313 0.81 EGFR (0.40) EGFRAURKBPLK4MAPK8MAPK9
SCHEMBL6974173 0.77 MGLL (0.39) EGFRGABRA1GABRG2GABRB3GABRA5
SCHEMBL6979231 0.68 EGFR (0.53) EGFRKMT2ALMNAMEN1L3MBTL1
SCHEMBL6980855 0.67 DNMT1 (0.36) EGFRGABRA1GABRG2GABRB3GABRA5
SCHEMBL6978311 0.67 L3MBTL1 (0.44) KMT2AKDM4EMEN1L3MBTL1ALDH1A1
SCHEMBL10313361 0.67 ALKBH5 (0.55) KMT2AKDM4ELMNAMEN1L3MBTL1
SCHEMBL19387982 0.66 MAPT (0.49) KMT2AKDM4EMEN1L3MBTL1ALDH1A1
SCHEMBL23723201 0.65 MAPT (0.46) KMT2AKDM4EMEN1L3MBTL1ALDH1A1
SCHEMBL28187352 0.65 MAPT (0.42) EGFRKMT2AKDM4ELMNAMEN1
SCHEMBL14575728 0.65 MAPK8 (0.53) MAPK8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0985671-B1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARM CO LTD (JP) 2003-04-02 EP disclosed
US-6197768-B1 THERAPY, PREVENTION ISCHEMIC HEART DISEASE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2001-03-06 US disclosed
EP-0985671-A1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-03-15 EP disclosed
US-6018046-A SELECTIVE ACTION IN INHIBITING CYCLIC GMP-PHOSPHODIESTERASE (CGMP-PDE); PHARMACEUTICALS FOR TREATING DISEASES AGAINST WHICH THE INHIBITORY ACTION IS EFFECTIVE, SUCH AS PULMONARY HYPERTENSION MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-01-25 US disclosed