Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 8/20 | 0.36 |
| ▸ | RARB | P10826 | 8/20 | 0.36 |
| ▸ | RARG | P13631 | 7/20 | 0.36 |
| ▸ | PPARG | P37231 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971025 | 0.86 | RARB (0.34) | RARARARBRARGPTGS1PTGS2 | |
| SCHEMBL7998817 | 0.86 | RARA (0.35) | RARARARBRARGPPARGKDM4E | |
| SCHEMBL7619004 | 0.78 | RARA (0.42) | RARARARBRARGPPARGPTGS1 | |
| SCHEMBL6970278 | 0.76 | KDM4E (0.37) | KDM4EHPGDHSD17B10JAK2ALDH1A1 | |
| SCHEMBL6971021 | 0.73 | RXRA (0.39) | RARARARBRARGPPARGPTGS1 | |
| SCHEMBL7831353 | 0.72 | PTGDR (0.36) | RARARARBRARGPTGS1PTGS2 | |
| SCHEMBL7501617 | 0.72 | KDM4E (0.40) | KDM4EHPGDHSD17B10JAK2ALDH1A1 | |
| SCHEMBL7809913 | 0.71 | KDM4E (0.33) | KDM4EHPGDHSD17B10JAK2ALDH1A1 | |
| SCHEMBL7624159 | 0.69 | RARA (0.41) | RARARARBRARGPPARGPTGS1 | |
| SCHEMBL7804185 | 0.69 | KDM4E (0.36) | KDM4EHPGDHSD17B10JAK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080089-B1 | PYRAZOLYLDIOXOTHIOCHROMANOYL DERIVATIVES | BASF AG (DE) | 2003-11-05 | — | — | EP | disclosed |
| EP-1080089-A1 | PYRAZOLYLDIOXOTHIOCHROMANOYL DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999059991-A1 | PYRAZOLYLDIOXOTHIOCHROMANOYL DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 1999-11-25 | — | — | WO | disclosed |