Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 11/20 | 0.34 |
| ▸ | RARG | P13631 | 11/20 | 0.34 |
| ▸ | RARA | P10276 | 10/20 | 0.34 |
| ▸ | RXRA | P19793 | 10/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 3/20 | 0.33 |
| ▸ | RXRG | P48443 | 3/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.33 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980246 | 0.86 | RARA (0.36) | RARBRARGRARARXRAPTGS1 | |
| SCHEMBL7831353 | 0.85 | PTGDR (0.36) | RARBRARGRARARXRAPTGS1 | |
| SCHEMBL6971021 | 0.78 | RXRA (0.39) | RARBRARGRARARXRAPTGS1 | |
| SCHEMBL7619004 | 0.75 | RARA (0.42) | RARBRARGRARARXRAPTGS1 | |
| SCHEMBL6977102 | 0.75 | MCL1 (0.31) | — | |
| SCHEMBL7998817 | 0.72 | RARA (0.35) | RARBRARGRARARXRAPTGS1 | |
| SCHEMBL6981392 | 0.71 | RXRA (0.33) | RARBRARGRARARXRARXRB | |
| SCHEMBL9197628 | 0.70 | RARB (0.43) | RARBRARGRARARXRARXRB | |
| SCHEMBL7813372 | 0.70 | KDM4E (0.38) | KMT2A | |
| SCHEMBL7496062 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080089-B1 | PYRAZOLYLDIOXOTHIOCHROMANOYL DERIVATIVES | BASF AG (DE) | 2003-11-05 | — | — | EP | disclosed |
| EP-1080089-A1 | PYRAZOLYLDIOXOTHIOCHROMANOYL DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999059991-A1 | PYRAZOLYLDIOXOTHIOCHROMANOYL DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 1999-11-25 | — | — | WO | disclosed |