SCHEMBL6980247

SCHEMBL6980247

Nc1nc(N)nc(C2CN(C(c3ccccc3)c3ccccc3)C2)n1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.40
GAA P10253 1/20 0.40
OPRM1 P35372 3/20 0.39
ADORA3 P0DMS8 2/20 0.39
CHRM2 P08172 1/20 0.39
CHRM4 P08173 1/20 0.39
CHRM5 P08912 1/20 0.39
ADRA2A P08913 1/20 0.39
CYP2D6 P10635 1/20 0.39
CHRM1 P11229 1/20 0.39
CHRM3 P20309 1/20 0.39
DRD1 P21728 1/20 0.39
ADRA1D P25100 1/20 0.39
HTR2A P28223 1/20 0.39
HTR2C P28335 1/20 0.39
HRH1 P35367 1/20 0.39
DRD3 P35462 1/20 0.39
HTR2B P41595 1/20 0.39
SLC6A3 Q01959 1/20 0.39
KCNH2 Q12809 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1740290 0.73 OPRM1 (0.47) ALDH1A1OPRM1ADORA3CHRM2CHRM4
SCHEMBL1603117 0.72 OPRD1 (0.48) ALDH1A1GAAOPRM1ADORA3CHRM2
SCHEMBL72466 0.71 OPRM1 (0.48) ALDH1A1OPRM1ADORA3CHRM2CHRM4
SCHEMBL6784509 0.70 OPRM1 (0.44) GAAOPRM1ADORA3CHRM2CHRM4
SCHEMBL6980526 0.70 CYP2D6 (0.43) OPRM1ADORA3CHRM2CHRM4CHRM5
Hydrochloric Acid SCHEMBL10506432 0.70 OPRM1 (0.47) ALDH1A1OPRM1ADORA3CHRM2CHRM4
Hydrochloric Acid SCHEMBL10401309 0.70 OPRM1 (0.47) ALDH1A1OPRM1ADORA3CHRM2CHRM4
SCHEMBL28205873 0.68 ATM (0.54) ALDH1A1GAAOPRM1CYP2D6MEN1
SCHEMBL21640161 0.68 OPRL1 (0.39) ALDH1A1GAAOPRM1ADORA3CHRM2
SCHEMBL48800 0.67 OPRM1 (0.48) ALDH1A1OPRM1ADORA3CHRM2CHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1037886-B1 TRIAZINE ANGIOGENESIS INHIBITORS ABBOTT LAB (US) 2003-05-02 EP claimed
US-6288228-B1 DIAMINOTRIAZINE DERIVATIVES ABBOTT LABORATORIES 2001-09-11 US claimed
US-6150362-A ADMINISTERING 1,3,5-SUBSTITUTED TRIAZINE COMPOUNDS TO THE PATIENT SUFFERING FROM ANGIOGENIC DISEASES ABBVIE INC. 2000-11-21 US claimed
EP-1037886-A1 TRIAZINE ANGIOGENESIS INHIBITORS Abbott Laboratories (US) 2000-09-27 EP claimed
WO-1999031088-A1 TRIAZINE ANGIOGENESIS INHIBITORS ABBOTT LABORATORIES (US) 1999-06-24 WO claimed
EP-1037886-B1 TRIAZINE ANGIOGENESIS INHIBITORS ABBOTT LAB (US) 2003-05-02 EP disclosed
US-6288228-B1 DIAMINOTRIAZINE DERIVATIVES ABBOTT LABORATORIES 2001-09-11 US disclosed
US-6150362-A ADMINISTERING 1,3,5-SUBSTITUTED TRIAZINE COMPOUNDS TO THE PATIENT SUFFERING FROM ANGIOGENIC DISEASES ABBVIE INC. 2000-11-21 US disclosed
EP-1037886-A1 TRIAZINE ANGIOGENESIS INHIBITORS Abbott Laboratories (US) 2000-09-27 EP disclosed
WO-1999031088-A1 TRIAZINE ANGIOGENESIS INHIBITORS ABBOTT LABORATORIES (US) 1999-06-24 WO disclosed