Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2951550 | 0.88 | HDAC1 (0.51) | ABCB1ABCC1PDE4APDE4BPDE4C | |
| SCHEMBL5177505 | 0.85 | HDAC1 (0.50) | MEN1KMT2AHDAC1HDAC6ALDH1A1 | |
| SCHEMBL2951697 | 0.81 | ROCK2 (0.41) | ABCB1ABCC1CYP46A1PDE4APDE4B | |
| SCHEMBL671044 | 0.79 | LOXL2 (0.48) | MEN1KMT2AROCK2ROCK1MAPK10 | |
| SCHEMBL2944876 | 0.76 | CHKA (0.66) | ABCB1ABCC1MEN1KMT2AHDAC1 | |
| SCHEMBL2952886 | 0.75 | SMN1; SMN2 (0.62) | PDE4BKMT2AALDH1A1SMN1; SMN2CHKA | |
| SCHEMBL2952031 | 0.74 | EGFR (0.51) | ADRB1ADRB3KMT2ASMN1; SMN2EGFR | |
| SCHEMBL2943927 | 0.74 | MAPT (0.53) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL2951105 | 0.73 | KDM1A (0.48) | MEN1KMT2AALDH1A1POLBCHKA | |
| SCHEMBL2951136 | 0.72 | EGFR (0.49) | PDE4APDE4BPDE4CPDE4DADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318978-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | Abbott Laboratories (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024636-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2002-03-28 | — | — | WO | disclosed |