Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981972 | 0.85 | MAPT (0.39) | LMNAMAPTKDM4ETSHRMAPK1 | |
| SCHEMBL6980777 | 0.81 | MAPT (0.45) | LMNAMAPTKDM4ETSHRMAPK1 | |
| SCHEMBL6998175 | 0.76 | GRIN2D (0.67) | GRIN2DGRIN3BCHRM1ADRA1DADRA1A | |
| SCHEMBL31647387 | 0.74 | MAPT (0.67) | LMNAMAPTKDM4ETSHRMAPK1 | |
| SCHEMBL27475432 | 0.71 | SLC2A1 (0.39) | LMNAMAPTKDM4ETSHRMAPK1 | |
| SCHEMBL31646673 | 0.69 | ALDH1A1 (0.46) | LMNAMAPTKDM4ETSHRMAPK1 | |
| SCHEMBL3405363 | 0.69 | CRHBP (0.61) | LMNAKDM4ETSHRMAPK1HSD17B10 | |
| SCHEMBL9884924 | 0.68 | EGFR (0.61) | LMNAMAPTKDM4ETSHRMAPK1 | |
| SCHEMBL2531188 | 0.68 | KMT2A (0.68) | MAPTKDM4ETSHRGAATDP1 | |
| SCHEMBL3410886 | 0.68 | CRHBP (0.64) | LMNAKDM4ETSHRMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0976745-B1 | 4-TETRAHYDROPYRIDYLPYRIMIDINE DERIVATIVES | TAISHO PHARMACEUTICAL CO LTD (JP) | 2003-08-13 | — | — | EP | disclosed |
| US-6187781-B1 | CORTICOTROPIN RELEASING FACTOR RECEPTOR ANTAGONISTS; ALZHEIMER*S, HUNTINGTON, AND PARKINSON DISEASE; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0976745-A1 | 4-TETRAHYDROPYRIDYLPYRIMIDINE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2000-02-02 | — | — | EP | disclosed |