Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | WNT1 | P04628 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4828091 | 0.88 | HPGDS (0.59) | SUCNR1CHRM3HPGDSBTKWNT1 | |
| SCHEMBL6974580 | 0.84 | WDR5 (0.56) | SUCNR1CHRM3ALDH1A1GAA | |
| SCHEMBL31721218 | 0.79 | CHRM3 (0.61) | SUCNR1CHRM3BTKWNT1GSK3B | |
| SCHEMBL27551430 | 0.76 | HPGDS (0.57) | SUCNR1CHRM3HPGDSBTKHDAC1 | |
| SCHEMBL31721288 | 0.76 | HPGDS (0.59) | CHRM3HPGDSBTKALDH1A1KDM4E | |
| SCHEMBL31721340 | 0.75 | CHRM3 (0.59) | SUCNR1CHRM3BTKHDAC1HDAC3 | |
| SCHEMBL6072051 | 0.74 | HDAC6 (0.57) | CHRM3BTKHDAC1HDAC3HDAC4 | |
| SCHEMBL6782706 | 0.74 | HPGDS (0.75) | SUCNR1HPGDSBTKALDH1A1KDM4E | |
| SCHEMBL28394388 | 0.74 | WNT1 (0.53) | SUCNR1CHRM3HPGDSBTKWNT1 | |
| SCHEMBL27964239 | 0.74 | HDAC6 (0.55) | SUCNR1HPGDSBTKHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1146542-C | Benzamide derivatives and their use as cytokine inhibitors | — | 2004-04-21 | — | — | CN | disclosed |
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |
| CN-1319092-A | Benzamide derivatives and their use as cytokine inhibitors | ASTRAZENECA AB (SE) | 2001-10-24 | — | — | CN | disclosed |
| EP-1115707-A1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018738-A1 | BENZAMIDE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2000-04-06 | — | — | WO | disclosed |