Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.76 |
| ▸ | ACHE | P22303 | 15/20 | 0.64 |
| ▸ | BACE1 | P56817 | 9/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3603394 | 0.83 | HRH3 (0.59) | HRH3ACHEBACE1KDM4EGAA | |
| SCHEMBL1748294 | 0.82 | HRH3 (0.53) | HRH3ACHEBACE1 | |
| SCHEMBL3359734 | 0.81 | DRD2 (0.71) | HRH3ACHEBACE1KDM4EGAA | |
| SCHEMBL1748228 | 0.80 | SSTR5 (0.56) | HRH3ACHEBACE1 | |
| SCHEMBL1748425 | 0.79 | SSTR5 (0.61) | HRH3ACHE | |
| SCHEMBL8310620 | 0.79 | HRH3 (0.64) | HRH3ACHEBACE1DRD2DRD4 | |
| SCHEMBL17544472 | 0.79 | MALT1 (0.57) | HRH3KDM4E | |
| SCHEMBL1748675 | 0.79 | SSTR5 (0.59) | HRH3ACHE | |
| SCHEMBL1748560 | 0.79 | SSTR5 (0.59) | HRH3KDM4E | |
| SCHEMBL5432812 | 0.78 | ACHE (0.69) | HRH3ACHEBACE1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |
| EP-0862560-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-09-09 | — | — | EP | disclosed |
| WO-1997019065-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |