SCHEMBL8310620

SCHEMBL8310620

CN(c1nccc(NC2CC2)n1)C1CCN(Cc2ccccc2)CC1

nearest known ligand 0.64

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.64
ACHE P22303 13/20 0.54
BACE1 P56817 8/20 0.52
CYP3A4 P08684 2/20 0.49
CYP2D6 P10635 2/20 0.49
GMNN O75496 1/20 0.49
ALDH1A1 P00352 1/20 0.49
LMNA P02545 1/20 0.49
TP53 P04637 1/20 0.49
DRD2 P14416 1/20 0.49
HPGD P15428 1/20 0.49
DRD4 P21917 1/20 0.49
DRD3 P35462 1/20 0.49
PMP22 Q01453 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
SLC2A1 P11166 1/20 0.48
CYP1A2 P05177 1/20 0.47
NSD2 O96028 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6590009 0.87 ACHE (0.52) HRH3ACHEBACE1CYP3A4CYP2D6
SCHEMBL6980975 0.79 HRH3 (0.76) HRH3ACHEBACE1DRD2DRD4
SCHEMBL8408405 0.78 DRD2 (0.62) HRH3ACHECYP3A4CYP2D6GMNN
SCHEMBL3644298 0.75 SLC2A1 (0.48) ACHECYP3A4CYP2D6GMNNALDH1A1
SCHEMBL6593436 0.75 SLC2A1 (0.56) HRH3ACHECYP3A4CYP2D6GMNN
SCHEMBL5174234 0.73 DRD2 (0.60) ACHECYP3A4CYP2D6GMNNALDH1A1
SCHEMBL3359734 0.73 DRD2 (0.71) HRH3ACHEBACE1DRD2DRD4
SCHEMBL21375648 0.72 SIGMAR1 (0.60) ACHECYP3A4CYP2D6GMNNALDH1A1
SCHEMBL6593675 0.71 ACHE (0.43) HRH3ACHEBACE1CYP3A4CYP2D6
SCHEMBL6597276 0.70 SLC2A1 (0.62) HRH3ACHECYP3A4CYP2D6GMNN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0912552-A1 2,4-DIAMINOPYRIMIDINE DERIVATES AS DOPAMINE D4 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 1999-05-06 EP claimed
WO-1997043279-A1 2,4-DIAMINOPYRIMIDINE DERIVATES AS DOPAMINE D4 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 1997-11-20 WO claimed
EP-0912552-A1 2,4-DIAMINOPYRIMIDINE DERIVATES AS DOPAMINE D4 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 1999-05-06 EP disclosed
WO-1997043279-A1 2,4-DIAMINOPYRIMIDINE DERIVATES AS DOPAMINE D4 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 1997-11-20 WO disclosed