Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.74 |
| ▸ | MAPT | P10636 | 6/20 | 0.74 |
| ▸ | GAA | P10253 | 4/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | CASP1 | P29466 | 1/20 | 0.74 |
| ▸ | CASP7 | P55210 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29612371 | 0.86 | KDM4E (1.00) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL379103 | 0.86 | KDM4E (1.00) | KDM4EMAPTGAAALDH1A1CASP1 | |
| Hydrochloric Acid SCHEMBL1372439 | 0.85 | KDM4E (0.97) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL4051892 | 0.79 | PTPN5 (0.62) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL13401405 | 0.78 | KDM4E (0.73) | KDM4EMAPTGAAALDH1A1CASP1 | |
| Indole SCHEMBL28345849 | 0.75 | KDM4E (0.76) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL5063952 | 0.74 | ALDH1A1 (0.66) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL28092663 | 0.74 | MAPT (0.76) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL15281758 | 0.74 | MAPT (0.76) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL3384593 | 0.73 | ATM (0.67) | KDM4EMAPTGAAALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218343-A4 | PYRIDINE CARBOXAMIDE OR SULFONAMIDE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2003-06-18 | — | — | EP | disclosed |
| EP-1218343-A1 | PYRIDINE CARBOXAMIDE OR SULFONAMIDE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION Bioscience AG (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001025203-A1 | PYRIDINE CARBOXAMIDE OR SULFONAMIDE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-04-12 | — | — | WO | disclosed |