Sugi Predict

Sugi Predict / Compounds / SCHEMBL698919

SCHEMBL698919

SCHEMBL698919

Cc1cccc([C@H](C)c2nccn2C(=O)OCc2ccc(Br)cc2)c1C

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 2/20 0.38
▸ TDP1 Q9NUW8 1/20 0.38
▸ KMT2A Q03164 2/20 0.36
▸ KDM4E B2RXH2 1/20 0.36
▸ LMNA P02545 3/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ FPR2 P25090 7/20 0.35
▸ HTT P42858 2/20 0.35
▸ MAPT P10636 2/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ MAOB P27338 2/20 0.34
▸ MAOA P21397 1/20 0.34
▸ MMP1 P03956 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ GRIN2B Q13224 1/20 0.34
▸ RAB9A P51151 1/20 0.33
▸ TRPV1 Q8NER1 1/20 0.33
▸ AAK1 Q2M2I8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL698126 0.92 GRIN2B (0.41) L3MBTL1TDP1KMT2AKDM4ELMNA
SCHEMBL697760 0.91 L3MBTL1 (0.38) L3MBTL1TDP1KMT2ALMNAALDH1A1
SCHEMBL696660 0.90 GRIN2B (0.38) L3MBTL1KMT2ALMNAMAPTMEN1
SCHEMBL696991 0.90 L3MBTL1 (0.40) L3MBTL1LMNAFPR2MAPTMAOB
SCHEMBL703335 0.90 GRIN2B (0.42) L3MBTL1KMT2AKDM4ELMNAHTT
SCHEMBL704575 0.89 FFAR1 (0.38) L3MBTL1RAB9A
SCHEMBL696627 0.89 GRIN2B (0.40) L3MBTL1TDP1KMT2ALMNAALDH1A1
SCHEMBL3533515 0.89 TP53 (0.40) L3MBTL1TDP1KMT2AKDM4ELMNA
SCHEMBL699044 0.88 FNTA (0.41) TDP1LMNAALDH1A1MAOBSMN1; SMN2
SCHEMBL698127 0.88 GRIN2B (0.41) L3MBTL1TDP1KMT2ALMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2423199-A1 Substituted imidazoles and their use as pesticides Pfizer Limited (GB) 2012-02-29 — — EP disclosed
US-7825149-B2 Substituted imidazoles PFIZER LIMITED (GB) 2010-11-02 — — US disclosed
US-20090312326-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2009-12-17 — — US disclosed
US-7592362-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-09-22 — — US disclosed
US-7547718-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-16 — — US disclosed
US-7544706-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-09 — — US disclosed
US-20080125473-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-29 — — US disclosed
US-20080119536-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-22 — — US disclosed
US-20070167506-A1 SUBSTITUTED IMIDAZOLES PFIZER INC. (US) 2007-07-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080125473-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 L3MBTL1 1548/4885TDP1 2820/4885KMT2A 945/4885
US-20090312326-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 L3MBTL1 1548/4885TDP1 2820/4885KMT2A 945/4885
US-20070167506-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 L3MBTL1 1548/4885TDP1 2820/4885KMT2A 945/4885
US-20080119536-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 L3MBTL1 1548/4885TDP1 2820/4885KMT2A 945/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.