Sugi Predict

Sugi Predict / Compounds / SCHEMBL696991

SCHEMBL696991

SCHEMBL696991

Cc1cccc([C@H](C)c2nccn2C(=O)OCc2ccc(Cl)cc2)c1C

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 3/20 0.40
▸ MAPK1 P28482 1/20 0.40
▸ P2RX4 Q99571 1/20 0.37
▸ FFAR1 O14842 3/20 0.35
▸ FPR2 P25090 1/20 0.34
▸ GRIN2B Q13224 2/20 0.34
▸ MMP1 P03956 1/20 0.34
▸ MMP2 P08253 1/20 0.34
▸ MMP9 P14780 1/20 0.34
▸ MMP12 P39900 1/20 0.34
▸ MAOA P21397 1/20 0.34
▸ MAOB P27338 1/20 0.34
▸ PTGES2 Q9H7Z7 1/20 0.34
▸ LMNA P02545 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ RAB9A P51151 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL703335 0.92 GRIN2B (0.42) L3MBTL1MAPK1FFAR1GRIN2BLMNA
SCHEMBL698126 0.92 GRIN2B (0.41) L3MBTL1P2RX4GRIN2BMMP1MMP2
SCHEMBL702018 0.91 FFAR1 (0.35) FFAR1FPR2LMNAMAPTRAB9A
SCHEMBL697760 0.91 L3MBTL1 (0.38) L3MBTL1P2RX4FFAR1GRIN2BLMNA
SCHEMBL697730 0.90 GRM5 (0.41) FFAR1MMP1MMP2MMP9MMP12
SCHEMBL697839 0.90 FPR2 (0.35) L3MBTL1MAPK1FFAR1FPR2PTGES2
SCHEMBL696660 0.90 GRIN2B (0.38) L3MBTL1FFAR1GRIN2BMMP1MMP2
SCHEMBL698919 0.90 L3MBTL1 (0.38) L3MBTL1FPR2GRIN2BMMP1MAOA
SCHEMBL697902 0.89 NPSR1 (0.42) L3MBTL1MAPK1FFAR1MAOAMAOB
SCHEMBL716667 0.89 KDM5A (0.37) FFAR1GRIN2BLMNAMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2423199-A1 Substituted imidazoles and their use as pesticides Pfizer Limited (GB) 2012-02-29 — — EP disclosed
US-7825149-B2 Substituted imidazoles PFIZER LIMITED (GB) 2010-11-02 — — US disclosed
US-20090312326-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2009-12-17 — — US disclosed
US-7592362-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-09-22 — — US disclosed
US-7547718-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-16 — — US disclosed
US-7544706-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-09 — — US disclosed
US-20080125473-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-29 — — US disclosed
US-20080119536-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-22 — — US disclosed
US-20070167506-A1 SUBSTITUTED IMIDAZOLES PFIZER INC. (US) 2007-07-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080125473-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 L3MBTL1 1548/4885MAPK1 3695/4885P2RX4 710/4885
US-20090312326-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 L3MBTL1 1548/4885MAPK1 3695/4885P2RX4 710/4885
US-20070167506-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 L3MBTL1 1548/4885MAPK1 3695/4885P2RX4 710/4885
US-20080119536-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 L3MBTL1 1548/4885MAPK1 3695/4885P2RX4 710/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.