Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 14/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 14/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 13/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | GNRHR | P30968 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976619 | 0.81 | TLR8 (0.43) | TLR8TLR7TLR9GNRHR | |
| SCHEMBL8695570 | 0.81 | KDM4E (0.45) | TLR8TLR7TLR9KDM4ESCN5A | |
| SCHEMBL8694369 | 0.73 | KDM4E (0.48) | KDM4ESCN5ASCN10A | |
| SCHEMBL7912408 | 0.71 | CYP1A2 (0.66) | HTR6GNRHR | |
| SCHEMBL7995810 | 0.70 | GNRHR (0.54) | GNRHR | |
| SCHEMBL7899399 | 0.69 | TLR8 (0.49) | TLR8TLR7TLR9HTR6GNRHR | |
| SCHEMBL8184086 | 0.69 | GNRHR (0.66) | GNRHR | |
| SCHEMBL7829040 | 0.69 | GNRHR (0.51) | GNRHR | |
| SCHEMBL27033015 | 0.68 | RAB9A (0.50) | — | |
| SCHEMBL6983816 | 0.68 | CXCR2 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095038-B1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 2003-09-03 | — | — | EP | disclosed |
| EP-0873336-B1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 2002-03-27 | — | — | EP | disclosed |
| EP-1095038-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 2001-05-02 | — | — | EP | disclosed |
| US-6200957-B1 | USEFUL FOR TREATMENT OF VARIETY OF SEX-HORMONE RELATED AND OTHER CONDITIONS IN BOTH MEN AND WOMEN | MERCK & CO., INC. | 2001-03-13 | — | — | US | disclosed |
| WO-2000004013-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 2000-01-27 | — | — | WO | disclosed |
| US-5780437-A | ADMINISTERING TO TREAT SEX-HORMONE RELATED DISORDERS | MERCK & CO., INC. (US) | 1998-07-14 | — | — | US | disclosed |