Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 3/20 | 0.36 |
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | UGCG | Q16739 | 2/20 | 0.36 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981334 | 1.00 | PDE4D (0.39) | PDE4DLTA4HKDM4EALDH1A1TDP1 | |
| SCHEMBL27469218 | 0.80 | ALDH1A1 (0.42) | KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL6979320 | 0.80 | KDM4E (0.51) | LTA4HKDM4EALDH1A1TDP1L3MBTL1 | |
| SCHEMBL8230399 | 0.77 | KDM4E (0.44) | KDM4EALDH1A1L3MBTL1GBA1 | |
| SCHEMBL11640859 | 0.77 | KDM4E (0.44) | KDM4EALDH1A1L3MBTL1GBA1 | |
| SCHEMBL11792482 | 0.76 | KDM4E (0.43) | KDM4EALDH1A1L3MBTL1GBA1EPHX2 | |
| SCHEMBL11792486 | 0.76 | KDM4E (0.43) | KDM4EALDH1A1L3MBTL1GBA1EPHX2 | |
| SCHEMBL9657925 | 0.73 | ALDH1A1 (0.41) | KDM4EALDH1A1L3MBTL1CYP2C19 | |
| SCHEMBL9674355 | 0.72 | DDB1 (0.41) | KDM4EALDH1A1GBA1 | |
| SCHEMBL4068078 | 0.72 | SIGMAR1 (0.53) | LTA4HTDP1L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | disclosed |
| US-6011028-A | Cyclic amidino agents useful as nitric oxide synthase inhibitors | G.D. SEARLE & CO. (US) | 2000-01-04 | — | — | US | disclosed |
| EP-0821674-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033175-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-10-24 | — | — | WO | disclosed |