Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | YAP1 | P46937 | 1/20 | 0.35 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HTR1E | P28566 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974191 | 0.79 | YAP1 (0.35) | TSHRYAP1TEAD4 | |
| SCHEMBL6971316 | 0.74 | RAB9A (0.38) | TSHR | |
| SCHEMBL10639565 | 0.73 | ALDH1A1 (0.34) | ALDH1A1HTT | |
| SCHEMBL6977408 | 0.71 | ALDH1A1 (0.55) | ALDH1A1 | |
| SCHEMBL27797853 | 0.69 | KMT2A (0.58) | TSHR | |
| SCHEMBL9413683 | 0.69 | MEN1 (0.40) | TSHRALDH1A1HTTHTR1ES1PR3 | |
| SCHEMBL435358 | 0.69 | FFAR1 (0.48) | ALDH1A1HTT | |
| SCHEMBL13715266 | 0.69 | FFAR1 (0.48) | ALDH1A1HTT | |
| SCHEMBL13715262 | 0.69 | FFAR1 (0.48) | ALDH1A1HTT | |
| SCHEMBL9540511 | 0.68 | SLC6A2 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | claimed |