Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.42 |
| ▸ | ACP3 | P15309 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10481598 | 0.81 | CA12 (0.48) | TSHRCYP2C9CA12CA1CA2 | |
| SCHEMBL3606244 | 0.81 | MIF (0.49) | TSHRCA12CA1CA2CA7 | |
| SCHEMBL9216101 | 0.79 | L3MBTL1 (0.49) | ALDH1A1KMT2ACYP1A2L3MBTL1MAPK1 | |
| SCHEMBL9711999 | 0.78 | ABCB11 (0.52) | TSHRCYP2C9ABCB11CA12CA1 | |
| SCHEMBL7128925 | 0.78 | ABCB11 (0.52) | TSHRCYP2C9ABCB11CA12CA1 | |
| SCHEMBL9772487 | 0.78 | CA12 (0.44) | TSHRCA12CA1CA2CA7 | |
| SCHEMBL8418152 | 0.77 | AOC3 (0.51) | TSHRABCB11AOC3L3MBTL1MAPK1 | |
| SCHEMBL8418151 | 0.77 | AOC3 (0.51) | TSHRABCB11AOC3L3MBTL1MAPK1 | |
| SCHEMBL17660055 | 0.77 | AOC3 (0.61) | TSHRCYP2C9ABCB11CA12CA1 | |
| SCHEMBL4372787 | 0.77 | AOC3 (0.61) | TSHRCYP2C9ABCB11CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289980-A1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090100-A1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-11-29 | — | — | WO | disclosed |