Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | DPP4 | P27487 | 1/20 | 0.56 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.56 |
| ▸ | CCR3 | P51677 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.53 |
| ▸ | PDE2A | O00408 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16002936 | 0.86 | PLK1 (0.55) | NPC1RAB9AHPGDDPP4DPP8 | |
| SCHEMBL13889100 | 0.85 | CCR3 (0.61) | CCR3LMNA | |
| SCHEMBL6981927 | 0.85 | DPP4 (0.59) | NPC1RAB9AHPGDDPP4DPP8 | |
| SCHEMBL16000517 | 0.84 | DPP4 (0.54) | NPC1RAB9AHPGDDPP4DPP8 | |
| SCHEMBL31428431 | 0.84 | CAPN1 (0.55) | NPC1RAB9AHPGDDPP4DPP8 | |
| SCHEMBL6986208 | 0.84 | HPGD (0.71) | HPGDDPP4DPP8ALDH1A1LMNA | |
| SCHEMBL13889099 | 0.83 | L3MBTL3 (0.67) | HPGDDPP4DPP8CCR3 | |
| SCHEMBL28256059 | 0.83 | HPGD (0.57) | HPGDDPP4DPP8CCR3ALDH1A1 | |
| SCHEMBL6984876 | 0.82 | MKNK1 (0.62) | HPGDDPP4DPP8CCR3ALOX15 | |
| SCHEMBL31428565 | 0.82 | RIPK1 (0.60) | HPGDDPP4DPP8CCR3ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991624-B1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-11-19 | — | — | EP | disclosed |
| US-6300342-B1 | FOR THERAPY OR INHIBITING THROMBUS FORMATION; FOR THERAPY OF FIBRIN-DEPENDENT INFLAMMATORY CONDITION | BOEHRINGER INGELHEIM PHARM KG (DE) | 2001-10-09 | — | — | US | disclosed |
| EP-0991624-A1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | Boehringer Ingelheim Pharma KG (DE) | 2000-04-12 | — | — | EP | disclosed |
| WO-1999000371-A1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-01-07 | — | — | WO | disclosed |