Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.71 |
| ▸ | DPP4 | P27487 | 1/20 | 0.67 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.57 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.56 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.54 |
| ▸ | PDE2A | O00408 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13889099 | 0.88 | L3MBTL3 (0.67) | HPGDDPP4DPP8 | |
| SCHEMBL28256059 | 0.87 | HPGD (0.57) | HPGDDPP4DPP8LMNAALDH1A1 | |
| SCHEMBL31428565 | 0.86 | RIPK1 (0.60) | HPGDDPP4DPP8RIPK1KDM4E | |
| SCHEMBL3296940 | 0.86 | HPGD (0.56) | HPGDDPP4DPP8LMNAALDH1A1 | |
| SCHEMBL6984876 | 0.86 | MKNK1 (0.62) | HPGDDPP4DPP8RIPK1SMN1; SMN2 | |
| SCHEMBL31428718 | 0.85 | HPGD (0.55) | HPGDDPP4DPP8LMNAALDH1A1 | |
| SCHEMBL6981541 | 0.84 | NPC1 (0.67) | HPGDDPP4DPP8LMNAALDH1A1 | |
| Ethylene SCHEMBL8381547 | 0.84 | HPGD (0.54) | HPGDDPP4DPP8LMNAALDH1A1 | |
| SCHEMBL20467479 | 0.84 | HPGD (1.00) | HPGD | |
| SCHEMBL14339821 | 0.83 | PKM (0.63) | HPGDDPP4DPP8LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105209041-A | Novel respiratory control modulating compounds and methods of use thereof | GALLEON PHARMACEUTICALS INC | 2015-12-30 | — | — | CN | disclosed |
| CN-104602694-A | Novel compounds and compositions for treatment of breathing control disorders or diseases | GALLEON PHARMACEUTICALS INC | 2015-05-06 | — | — | CN | disclosed |
| EP-0991624-B1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-11-19 | — | — | EP | disclosed |
| US-6300342-B1 | FOR THERAPY OR INHIBITING THROMBUS FORMATION; FOR THERAPY OF FIBRIN-DEPENDENT INFLAMMATORY CONDITION | BOEHRINGER INGELHEIM PHARM KG (DE) | 2001-10-09 | — | — | US | disclosed |
| EP-0991624-A1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | Boehringer Ingelheim Pharma KG (DE) | 2000-04-12 | — | — | EP | disclosed |
| WO-1999000371-A1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-01-07 | — | — | WO | disclosed |