Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.53 |
| ▸ | BCL2 | P10415 | 2/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2625197 | 0.85 | BCL2 (0.61) | PARP10SRD5A2BCL2MCL1NPY5R | |
| SCHEMBL649287 | 0.82 | KMT2A (0.55) | PTGS1ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8823334 | 0.82 | KMT2A (0.55) | PTGS1ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11691009 | 0.82 | PARP10 (0.55) | PARP10SRD5A2BCL2MCL1NPY5R | |
| SCHEMBL11433567 | 0.82 | PARP10 (0.55) | PARP10SRD5A2BCL2MCL1NPY5R | |
| SCHEMBL6554648 | 0.81 | ALDH1A1 (0.64) | PARP10ALDH1A1RAB9ANPC1POLB | |
| SCHEMBL11431494 | 0.81 | PARP10 (0.50) | PARP10SRD5A2BCL2MCL1NPY5R | |
| Hydrochloric Acid SCHEMBL9642871 | 0.81 | PARP10 (0.58) | PARP10SRD5A2BCL2MCL1NPY5R | |
| SCHEMBL6975810 | 0.79 | SMN1; SMN2 (0.57) | ALDH1A1RAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL11367866 | 0.79 | BCL2 (0.52) | PARP10SRD5A2BCL2MCL1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109560-B1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMA (US) | 2003-08-27 | — | — | EP | disclosed |
| US-6525050-B1 | Inhibit the enzyme aminoimidazole carboxamide ribonucleotide formyl transferase; antiproliferative agents; antitumor, antiinflammatory, antipsoriatic, and/or immunosuppressive | AGOURON PHARMACEUTICALS, INC. | 2003-02-25 | — | — | US | disclosed |
| EP-1109560-A4 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMA (US) | 2002-04-17 | — | — | EP | disclosed |
| EP-1109560-A1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000013688-A1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 2000-03-16 | — | — | WO | disclosed |