Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TCF4 | P15884 | 2/20 | 0.78 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.78 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.54 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16116948 | 0.88 | TCF4 (1.00) | TCF4CTNNB1POLBSMN1; SMN2LMNA | |
| SCHEMBL31253926 | 0.88 | TCF4 (1.00) | TCF4CTNNB1POLBSMN1; SMN2LMNA | |
| SCHEMBL14896438 | 0.88 | TCF4 (0.80) | TCF4CTNNB1POLBSMN1; SMN2LMNA | |
| SCHEMBL8369354 | 0.87 | TCF4 (0.80) | TCF4CTNNB1POLBSMN1; SMN2LMNA | |
| SCHEMBL10093371 | 0.87 | TCF4 (0.64) | TCF4CTNNB1POLBSMN1; SMN2LMNA | |
| SCHEMBL16116951 | 0.86 | TCF4 (1.00) | TCF4CTNNB1POLBSMN1; SMN2LMNA | |
| SCHEMBL16116946 | 0.84 | TCF4 (0.74) | TCF4CTNNB1POLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL3088571 | 0.83 | ATIC (0.70) | TCF4CTNNB1POLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL2896310 | 0.83 | TCF4 (0.73) | TCF4CTNNB1POLBSMN1; SMN2LMNA | |
| SCHEMBL1126864 | 0.83 | LMNA (0.64) | TCF4CTNNB1POLBL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109560-B1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMA (US) | 2003-08-27 | — | — | EP | disclosed |
| US-6525050-B1 | Inhibit the enzyme aminoimidazole carboxamide ribonucleotide formyl transferase; antiproliferative agents; antitumor, antiinflammatory, antipsoriatic, and/or immunosuppressive | AGOURON PHARMACEUTICALS, INC. | 2003-02-25 | — | — | US | disclosed |
| EP-1109560-A4 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMA (US) | 2002-04-17 | — | — | EP | disclosed |
| EP-1109560-A1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000013688-A1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 2000-03-16 | — | — | WO | disclosed |