Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL547913 | 0.86 | ALDH1A1 (0.44) | ALDH1A1HSD17B10HPGDBCL2L1BACE1 | |
| SCHEMBL291792 | 0.81 | ALDH1A1 (0.46) | ALDH1A1HSD17B10HPGDBCL2L1BACE1 | |
| SCHEMBL29833702 | 0.81 | ALDH1A1 (0.46) | ALDH1A1HSD17B10HPGDBCL2L1BACE1 | |
| SCHEMBL9755709 | 0.80 | NR4A2 (0.40) | ALDH1A1HSD17B10MAPK1MEN1KMT2A | |
| SCHEMBL13103919 | 0.79 | HSD11B1 (0.41) | ALDH1A1HSD17B10HPGDBCL2L1ESR2 | |
| SCHEMBL11639685 | 0.79 | ALDH1A1 (0.39) | ALDH1A1HSD17B10HPGDBCL2L1BACE1 | |
| SCHEMBL16387926 | 0.79 | PDCD1 (0.39) | ALDH1A1HSD17B10HPGDBCL2L1BACE1 | |
| SCHEMBL27721857 | 0.79 | TRPA1 (0.45) | ALDH1A1HSD17B10HPGDBCL2L1BACE1 | |
| Bicarbonate SCHEMBL27754489 | 0.78 | ALDH1A1 (0.45) | ALDH1A1HSD17B10HPGDBCL2L1HDAC4 | |
| Bicarbonate SCHEMBL27471685 | 0.78 | ALDH1A1 (0.45) | ALDH1A1HSD17B10HPGDBCL2L1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299379-A2 | LACTAM METALLOPROTEASE INHIBITORS | Bristol-Myers Squibb Pharma Company (US) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002004416-A2 | LACTAM METALLOPROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2002-01-17 | — | — | WO | disclosed |