Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5841954 | 0.92 | KMT2A (0.50) | MEN1KMT2AHTR1AHTR7KDM4E | |
| Fumaric Acid SCHEMBL5841948 | 0.92 | KMT2A (0.50) | MEN1KMT2AHTR1AHTR7KDM4E | |
| SCHEMBL6982652 | 0.82 | HRH3 (0.42) | HTR1AHTR7SIGMAR1HRH3 | |
| SCHEMBL5842805 | 0.81 | HRH3 (0.63) | MEN1SIGMAR1HRH3 | |
| SCHEMBL5841418 | 0.79 | MGLL (0.50) | KDM4EALDH1A1HRH3 | |
| SCHEMBL5840560 | 0.79 | HRH3 (0.43) | KDM4ESIGMAR1HRH3 | |
| SCHEMBL6976146 | 0.77 | HRH3 (0.62) | MEN1HRH3 | |
| SCHEMBL3583983 | 0.76 | CYP2D6 (0.60) | MEN1KMT2AHTR7KDM4EL3MBTL1 | |
| SCHEMBL5840444 | 0.76 | MEN1 (0.49) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| Fumaric Acid SCHEMBL5841727 | 0.76 | ACHE (0.43) | KMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |