Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 4/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5841723 | 0.92 | ACHE (0.43) | HRH3KCNJ1HRH2HRH1 | |
| Fumaric Acid SCHEMBL5841727 | 0.92 | ACHE (0.43) | HRH3KCNJ1HRH2HRH1 | |
| SCHEMBL5841718 | 0.83 | SLC29A1 (0.44) | HRH3SIGMAR1 | |
| SCHEMBL5842805 | 0.82 | HRH3 (0.63) | HRH3HRH2HRH1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL5841791 | 0.82 | SLC29A1 (0.43) | HRH3SIGMAR1 | |
| SCHEMBL6981970 | 0.82 | MEN1 (0.48) | HRH3HTR1AHTR7SIGMAR1 | |
| SCHEMBL5840560 | 0.82 | HRH3 (0.43) | HRH3NSD2EHMT2HRH2HRH1 | |
| SCHEMBL5841418 | 0.80 | MGLL (0.50) | HRH3HRH1 | |
| SCHEMBL6976146 | 0.79 | HRH3 (0.62) | HRH3HRH2HRH1 | |
| SCHEMBL5840444 | 0.77 | MEN1 (0.49) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |