Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 6/20 | 0.51 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.35 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4944058 | 0.89 | AVPR1A (0.65) | OXTRAVPR1AMEN1GAAMAPT | |
| SCHEMBL4944054 | 0.89 | AVPR1A (0.65) | OXTRAVPR1AMEN1GAAMAPT | |
| SCHEMBL4942034 | 0.88 | OXTR (0.58) | OXTRAVPR1AMEN1GAAMAPT | |
| SCHEMBL4942028 | 0.88 | OXTR (0.58) | OXTRAVPR1AMEN1GAAMAPT | |
| SCHEMBL5043513 | 0.87 | AVPR1A (0.62) | OXTRAVPR1AROCK2EPHX1AVPR2 | |
| SCHEMBL16550680 | 0.80 | AVPR1A (0.78) | OXTRAVPR1AROCK2PDK2EPHX1 | |
| SCHEMBL16550611 | 0.80 | AVPR1A (0.78) | OXTRAVPR1AROCK2PDK2EPHX1 | |
| SCHEMBL28754783 | 0.80 | AVPR1A (0.78) | OXTRAVPR1AROCK2PDK2EPHX1 | |
| SCHEMBL16550612 | 0.80 | AVPR1A (0.78) | OXTRAVPR1AROCK2PDK2EPHX1 | |
| SCHEMBL5474456 | 0.78 | OXTR (0.61) | OXTRAVPR1AMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268418-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074769-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-11 | — | — | WO | disclosed |