Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 7/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5434005 | 0.96 | KDM4E (0.51) | KDM4ENPC1PKMRAB9ASMN1; SMN2 | |
| SCHEMBL5419829 | 0.84 | ALDH1A1 (0.41) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL6984320 | 0.74 | APP (0.72) | KDM4ENPC1PKMRAB9ASMN1; SMN2 | |
| SCHEMBL2136886 | 0.73 | KDM4E (0.54) | KDM4ENPC1PKMRAB9ASMN1; SMN2 | |
| SCHEMBL19435575 | 0.72 | KDM4E (0.48) | KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2676990 | 0.71 | ALDH1A1 (0.57) | KDM4E | |
| SCHEMBL34471465 | 0.71 | CYP3A4 (0.45) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL10032140 | 0.70 | APP (0.52) | KDM4ENPC1PKMRAB9ASMN1; SMN2 | |
| SCHEMBL5419850 | 0.70 | SULT1A1 (0.70) | KDM4ENPC1PKMRAB9ASMN1; SMN2 | |
| SCHEMBL5429982 | 0.68 | APP (0.83) | KDM4ENPC1PKMRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345914-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002051821-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2002-07-04 | — | — | WO | disclosed |