Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.42 |
| ▸ | GNRHR | P30968 | 12/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982758 | 0.89 | HDAC1 (0.42) | HDAC1HDAC3HDAC2NCOR2GNRHR | |
| SCHEMBL6984825 | 0.80 | GNRHR (0.45) | GNRHR | |
| SCHEMBL6983626 | 0.80 | HDAC1 (0.48) | HDAC1HDAC3HDAC2NCOR2GNRHR | |
| SCHEMBL7084004 | 0.79 | GNRHR (0.43) | GNRHR | |
| SCHEMBL6977603 | 0.78 | HDAC1 (0.47) | HDAC1HDAC3HDAC2NCOR2GNRHR | |
| SCHEMBL6982756 | 0.78 | HDAC1 (0.41) | HDAC1HDAC3HDAC2NCOR2GNRHR | |
| SCHEMBL6978805 | 0.76 | HDAC1 (0.45) | HDAC1HDAC3HDAC2NCOR2GNRHR | |
| SCHEMBL6983847 | 0.73 | GNRHR (0.60) | GNRHR | |
| SCHEMBL8555783 | 0.70 | DAPK3 (0.46) | GNRHR | |
| SCHEMBL6980844 | 0.69 | GNRHR (0.45) | GNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095038-B1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 2003-09-03 | — | — | EP | disclosed |
| EP-0873336-B1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 2002-03-27 | — | — | EP | disclosed |
| EP-1095038-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 2001-05-02 | — | — | EP | disclosed |
| US-6200957-B1 | USEFUL FOR TREATMENT OF VARIETY OF SEX-HORMONE RELATED AND OTHER CONDITIONS IN BOTH MEN AND WOMEN | MERCK & CO., INC. | 2001-03-13 | — | — | US | disclosed |
| WO-2000004013-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 2000-01-27 | — | — | WO | disclosed |