SCHEMBL6982756

SCHEMBL6982756

CCCCC(CCC)Cc1cccn1-c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCN(Cc3ccccc3)C(=O)OC(C)(C)C)c2c1

nearest known ligand 0.42

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 3/20 0.41
HDAC3 O15379 2/20 0.40
HDAC2 Q92769 2/20 0.40
NCOR2 Q9Y618 2/20 0.40
GNRHR P30968 9/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6984830 0.81 GNRHR (0.43) GNRHR
SCHEMBL7084005 0.80 GNRHR (0.41) GNRHR
SCHEMBL6982758 0.78 HDAC1 (0.42) HDAC1HDAC3HDAC2NCOR2GNRHR
SCHEMBL6982755 0.78 HDAC1 (0.42) HDAC1HDAC3HDAC2NCOR2GNRHR
SCHEMBL6983626 0.78 HDAC1 (0.48) HDAC1HDAC3HDAC2NCOR2GNRHR
SCHEMBL6977603 0.76 HDAC1 (0.47) HDAC1HDAC3HDAC2NCOR2GNRHR
SCHEMBL6978805 0.74 HDAC1 (0.45) HDAC1HDAC3HDAC2NCOR2GNRHR
SCHEMBL8555783 0.67 DAPK3 (0.46) GNRHR
SCHEMBL7907209 0.62 GNRHR (0.54) GNRHR
SCHEMBL9060170 0.61 HDAC1 (0.60) HDAC1HDAC3HDAC2NCOR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1095038-B1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO INC (US) 2003-09-03 EP disclosed
EP-0873336-B1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO INC (US) 2002-03-27 EP disclosed
EP-1095038-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE Merck & Co., Inc. (US) 2001-05-02 EP disclosed
US-6200957-B1 USEFUL FOR TREATMENT OF VARIETY OF SEX-HORMONE RELATED AND OTHER CONDITIONS IN BOTH MEN AND WOMEN MERCK & CO., INC. 2001-03-13 US disclosed
WO-2000004013-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO., INC. (US) 2000-01-27 WO disclosed