Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 6/20 | 0.45 |
| ▸ | LPAR5 | Q9H1C0 | 6/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582986 | 0.85 | TDP1 (0.48) | KDM4EALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL4832284 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1TDP1GAAKMT2A | |
| SCHEMBL4837125 | 0.76 | KDM4E (0.49) | KDM4EALDH1A1TDP1GAAKMT2A | |
| SCHEMBL20491096 | 0.69 | EPHX2 (0.45) | KDM4EALDH1A1TDP1GAAKMT2A | |
| SCHEMBL5410659 | 0.69 | TDP1 (0.53) | KDM4EALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL14357373 | 0.69 | TDP1 (0.55) | KDM4EALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL5399087 | 0.68 | ALDH1A1 (0.53) | KDM4EALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL14357374 | 0.68 | ALDH1A1 (0.53) | KDM4EALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL5396564 | 0.67 | TDP1 (0.48) | KDM4EALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL25342155 | 0.66 | ALDH1A1 (0.47) | KDM4EALDH1A1TDP1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289950-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1289972-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1289953-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096304-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |
| WO-2001096323-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |
| WO-2001096296-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |