Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 6/20 | 0.44 |
| ▸ | LPAR5 | Q9H1C0 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982829 | 0.85 | KDM4E (0.51) | TDP1ALDH1A1KDM4ELPAR1LPAR5 | |
| SCHEMBL5396573 | 0.75 | TDP1 (0.50) | TDP1ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL5399746 | 0.74 | TDP1 (0.47) | TDP1ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL5410659 | 0.72 | TDP1 (0.53) | TDP1ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL14357373 | 0.71 | TDP1 (0.55) | TDP1ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL15366455 | 0.70 | ALDH1A1 (0.47) | ALDH1A1KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5243554 | 0.70 | ALDH1A1 (0.48) | TDP1ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL14357374 | 0.69 | ALDH1A1 (0.53) | TDP1ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL5399087 | 0.69 | ALDH1A1 (0.53) | TDP1ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL5706251 | 0.69 | L3MBTL1 (0.58) | TDP1ALDH1A1KMT2ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1455788-A1 | 1-GLYCINYL-4-AMINOMETHYL-PIPERIDINE DERIVATIVES AS FACTOR XA INHIBITORS | ELI LILLY AND COMPANY (US) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003049737-A1 | CHEMICAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2003-06-19 | — | — | WO | disclosed |