Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.43 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8384945 | 1.00 | ADRA1D (0.43) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| Fumaric Acid SCHEMBL6982903 | 1.00 | ADRA1D (0.43) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| Fumaric Acid SCHEMBL8384949 | 1.00 | ADRA1D (0.43) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL6977090 | 0.95 | ADRA1D (0.47) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL8384932 | 0.83 | ADRA1D (0.55) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL6980379 | 0.83 | ADRA1D (0.55) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL6981556 | 0.81 | ADRA1D (0.46) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL8383034 | 0.81 | ADRA1D (0.46) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL6972959 | 0.80 | ADRA1D (0.47) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL8386689 | 0.79 | ADRA1D (0.50) | ADRA1DADRA1AADRA1BHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839145-B1 | HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2003-11-05 | — | — | EP | disclosed |