Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPID | Q08752 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PPIB | P23284 | 1/20 | 0.40 |
| ▸ | PPIA | P62937 | 1/20 | 0.40 |
| ▸ | PPIG | Q13427 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977901 | 0.85 | CNR1 (0.41) | MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL7819154 | 0.84 | CNR1 (0.36) | HTTMAPTGAAALDH1A1L3MBTL1 | |
| SCHEMBL6970913 | 0.83 | OPRM1 (0.45) | HTTMAPTGAAALDH1A1MEN1 | |
| SCHEMBL6983251 | 0.80 | GAA (0.47) | HTTMAPTGAAALDH1A1APP | |
| SCHEMBL6979573 | 0.78 | OPRM1 (0.49) | HTTMAPTGAAMEN1KMT2A | |
| SCHEMBL6977165 | 0.76 | OPRM1 (0.38) | MAPTGAAMEN1KMT2AAPP | |
| SCHEMBL6978140 | 0.75 | OPRM1 (0.49) | GAAL3MBTL1 | |
| SCHEMBL6967893 | 0.75 | CNR1 (0.40) | MAPTALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL6980629 | 0.74 | APP (0.41) | MAPTGAAALDH1A1HPGDMEN1 | |
| SCHEMBL7145811 | 0.74 | APP (0.38) | HTTMAPTGAAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |