Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | WDR91 | A4D1P6 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.35 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.35 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.35 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983068 | 0.85 | PPID (0.46) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6967893 | 0.81 | CNR1 (0.40) | CNR1KMT2AALDH1A1MAPT | |
| SCHEMBL377756 | 0.76 | MAPK1 (0.40) | CNR1WDR91KMT2AALDH1A1 | |
| SCHEMBL6970913 | 0.75 | OPRM1 (0.45) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL6982434 | 0.75 | ALDH1A1 (0.44) | CNR1KMT2AALDH1A1MAPTEPHX2 | |
| SCHEMBL6981777 | 0.71 | AKR1C1 (0.41) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6975695 | 0.70 | POLB (0.38) | MEN1KMT2AALDH1A1 | |
| SCHEMBL25362579 | 0.69 | KDM4E (0.50) | ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL6981407 | 0.69 | CNR1 (0.37) | CNR1ALDH1A1 | |
| SCHEMBL6977165 | 0.69 | OPRM1 (0.38) | MEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |