Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982434 | 0.84 | ALDH1A1 (0.44) | L3MBTL1MAPTALDH1A1 | |
| SCHEMBL9337866 | 0.82 | GAA (0.59) | GAAOPRM1LMNAALDH1A1 | |
| SCHEMBL6970913 | 0.81 | OPRM1 (0.45) | GAAAPPL3MBTL1OPRM1MAPT | |
| SCHEMBL7815962 | 0.80 | OPRM1 (0.35) | GAAAPPL3MBTL1OPRM1MAPT | |
| SCHEMBL6983068 | 0.80 | PPID (0.46) | GAAAPPL3MBTL1MAPTALDH1A1 | |
| SCHEMBL6980629 | 0.80 | APP (0.41) | GAAAPPL3MBTL1OPRM1MAPT | |
| SCHEMBL6979573 | 0.76 | OPRM1 (0.49) | GAAOPRM1MAPTABCB11LMNA | |
| SCHEMBL6983604 | 0.73 | OPRM1 (0.41) | GAAOPRM1MAPTABCB11LMNA | |
| SCHEMBL9480815 | 0.73 | GAA (0.50) | GAAL3MBTL1OPRM1 | |
| SCHEMBL7145811 | 0.73 | APP (0.38) | GAAAPPL3MBTL1OPRM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |