Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.57 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.46 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10953965 | 0.78 | HRH3 (0.88) | HRH3PABPC1POLBCXCR4CXCL12 | |
| SCHEMBL3249083 | 0.76 | DPP7 (0.48) | HRH3DPP7CXCR4CXCL12KDM4E | |
| SCHEMBL5864236 | 0.70 | HRH3 (0.72) | HRH3POLBCXCR4CXCL12HDAC1 | |
| SCHEMBL21799935 | 0.70 | HRH3 (0.72) | HRH3PABPC1POLBCXCR4CXCL12 | |
| SCHEMBL5863541 | 0.70 | HRH3 (0.67) | HRH3POLBCXCR4CXCL12HDAC1 | |
| SCHEMBL11615671 | 0.70 | POLB (0.93) | HRH3POLBCXCR4CXCL12HDAC1 | |
| SCHEMBL3862351 | 0.70 | HRH3 (0.72) | HRH3PABPC1POLBCXCR4CXCL12 | |
| SCHEMBL5863714 | 0.70 | POLB (0.93) | HRH3POLBCXCR4CXCL12HDAC1 | |
| SCHEMBL1042778 | 0.70 | HRH3 (0.72) | HRH3PABPC1POLBCXCR4CXCL12 | |
| SCHEMBL4600037 | 0.70 | HRH3 (0.72) | HRH3POLBCXCR4CXCL12USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268434-A1 | CYCLIC LACTAMS AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074784-A1 | CYCLIC LACTAMS AS INHIBITORS OF A-β PROTEIN PRODUCTION | DUPONT PHARMACEUTICALS COMPANY (US) | 2001-10-11 | — | — | WO | disclosed |