SCHEMBL6983337

SCHEMBL6983337

CC(C)(C)OC(=O)COc1cc2c(=O)c(Cc3ccccn3)cn3c4ccc(Br)cc4c(c1)c23

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PSEN1 P49768 1/20 0.34
PSEN2 P49810 1/20 0.34
APH1B Q8WW43 1/20 0.34
NCSTN Q92542 1/20 0.34
APH1A Q96BI3 1/20 0.34
PSENEN Q9NZ42 1/20 0.34
TOP2A P11388 1/20 0.34
TOP2B Q02880 1/20 0.34
PTPN1 P18031 2/20 0.33
MAPT P10636 3/20 0.33
CYP2C9 P11712 2/20 0.33
CYP2C19 P33261 2/20 0.33
LMNA P02545 1/20 0.33
POLB P06746 1/20 0.33
HPGD P15428 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
HRH1 P35367 1/20 0.33
HTR6 P50406 1/20 0.33
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6980559 0.86 FPR1 (0.35) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6981607 0.84 KDM4E (0.40) TOP2ATOP2BMAPTHRH1HTR6
SCHEMBL6984474 0.83 TNFRSF1A (0.36) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6978516 0.82 TOP2A (0.38) TOP2ATOP2BMAPTCYP2C9CYP2C19
SCHEMBL6974001 0.79 PSEN1 (0.35) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6981400 0.78 PSEN1 (0.39) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6983182 0.75 TSHR (0.41) MAPTCYP2C9LMNAPOLBHPGD
SCHEMBL6981489 0.75 FPR1 (0.36) MAPTCYP2C9CYP2C19KDM4EALDH1A1
SCHEMBL6982874 0.75 MCL1 (0.36) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6975197 0.74 ALDH1A1 (0.36) MAPTCYP2C9CYP2C19KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0985671-B1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARM CO LTD (JP) 2003-04-02 EP disclosed
EP-0985671-A1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-03-15 EP disclosed
US-6018046-A SELECTIVE ACTION IN INHIBITING CYCLIC GMP-PHOSPHODIESTERASE (CGMP-PDE); PHARMACEUTICALS FOR TREATING DISEASES AGAINST WHICH THE INHIBITORY ACTION IS EFFECTIVE, SUCH AS PULMONARY HYPERTENSION MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-01-25 US disclosed