SCHEMBL6984474

SCHEMBL6984474

Cc1cn2c3ccc(Br)cc3c3cc(OCC(=O)OC(C)(C)C)cc(c1=O)c32

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNFRSF1A P19438 1/20 0.36
LMNA P02545 3/20 0.36
PSEN1 P49768 2/20 0.36
PSEN2 P49810 2/20 0.36
APH1B Q8WW43 2/20 0.36
NCSTN Q92542 2/20 0.36
APH1A Q96BI3 2/20 0.36
PSENEN Q9NZ42 2/20 0.36
IDO1 P14902 2/20 0.35
MAPT P10636 3/20 0.35
HPGD P15428 2/20 0.35
NPSR1 Q6W5P4 2/20 0.35
POLB P06746 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
THRB P10828 2/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
THRA P10827 1/20 0.33
KRAS P01116 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6983087 0.88 LMNA (0.44) LMNAPSEN1PSEN2APH1BNCSTN
SCHEMBL6975925 0.87 PTGDR2 (0.41) LMNAHPGDTHRBMEN1KMT2A
SCHEMBL6976583 0.86 LMNA (0.40) LMNAIDO1MAPTNPSR1THRB
SCHEMBL6981400 0.85 PSEN1 (0.39) TNFRSF1ALMNAPSEN1PSEN2APH1B
SCHEMBL6983337 0.83 PSEN1 (0.34) TNFRSF1ALMNAPSEN1PSEN2APH1B
SCHEMBL6980559 0.81 FPR1 (0.35) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6984498 0.79 LMNA (0.36) LMNAIDO1MAPTTHRBKDM4E
SCHEMBL6979851 0.79 LMNA (0.41) LMNAIDO1POLBMEN1KMT2A
SCHEMBL6975262 0.78 PIK3R1 (0.38) LMNAIDO1MAPTHPGDNPSR1
SCHEMBL6978017 0.77 PSEN1 (0.43) TNFRSF1ALMNAPSEN1PSEN2APH1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0985671-B1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARM CO LTD (JP) 2003-04-02 EP disclosed
US-6197768-B1 THERAPY, PREVENTION ISCHEMIC HEART DISEASE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2001-03-06 US disclosed
EP-0992240-A1 THERAPEUTIC AGENT FOR ERECTION FAILURE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-04-12 EP disclosed
EP-0985671-A1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-03-15 EP disclosed
US-6018046-A SELECTIVE ACTION IN INHIBITING CYCLIC GMP-PHOSPHODIESTERASE (CGMP-PDE); PHARMACEUTICALS FOR TREATING DISEASES AGAINST WHICH THE INHIBITORY ACTION IS EFFECTIVE, SUCH AS PULMONARY HYPERTENSION MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-01-25 US disclosed