Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | BMP1 | P13497 | 9/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982036 | 0.95 | BMP1 (0.32) | PPARGBMP1MMP2BCHETGFBR1 | |
| SCHEMBL6982855 | 0.91 | TGFBR1 (0.31) | TGFBR1 | |
| SCHEMBL6987056 | 0.83 | MMP2 (0.35) | PPARGBMP1MMP2 | |
| SCHEMBL6979963 | 0.80 | PPARG (0.33) | PPARGBMP1MMP2BCHE | |
| SCHEMBL6981859 | 0.78 | BMP1 (0.34) | BMP1MMP2 | |
| SCHEMBL6981509 | 0.77 | PPARG (0.32) | PPARGBMP1MMP2BCHETGFBR1 | |
| SCHEMBL6987230 | 0.76 | BMP1 (0.31) | PPARGBMP1MMP2BCHE | |
| SCHEMBL6982618 | 0.73 | BMP1 (0.35) | BMP1 | |
| SCHEMBL6980503 | 0.72 | TGFBR1 (0.35) | TGFBR1 | |
| SCHEMBL6988228 | 0.71 | TGFBR1 (0.30) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |