Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4949503 | 1.00 | ALDH1A1 (0.48) | ALDH1A1KMT2AMEN1CYP2C19USP2 | |
| SCHEMBL4949498 | 1.00 | ALDH1A1 (0.48) | ALDH1A1KMT2AMEN1CYP2C19USP2 | |
| SCHEMBL7219644 | 0.94 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1CYP2C19USP2 | |
| SCHEMBL4938283 | 0.94 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1CYP2C19USP2 | |
| SCHEMBL4945310 | 0.79 | ALDH1A1 (0.48) | ALDH1A1KMT2AMEN1CYP2C19USP2 | |
| SCHEMBL4943162 | 0.79 | ALDH1A1 (0.48) | ALDH1A1KMT2AMEN1CYP2C19USP2 | |
| SCHEMBL7090117 | 0.74 | OXTR (0.67) | ALDH1A1KMT2AMEN1CYP2C19USP2 | |
| SCHEMBL4945261 | 0.74 | OXTR (0.67) | ALDH1A1KMT2AMEN1CYP2C19USP2 | |
| SCHEMBL7090115 | 0.74 | OXTR (0.67) | ALDH1A1KMT2AMEN1CYP2C19USP2 | |
| SCHEMBL4942737 | 0.73 | ALDH1A1 (0.47) | ALDH1A1KMT2AMEN1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268419-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072705-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-04 | — | — | WO | disclosed |