Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12856209 | 0.84 | POLB (0.50) | MAPTHCN4CYP3A4ALOX15POLB | |
| SCHEMBL6981825 | 0.81 | KCNH2 (0.48) | L3MBTL1 | |
| SCHEMBL4874251 | 0.81 | SIGMAR1 (0.44) | MAPTHCN4CYP3A4ALOX15POLB | |
| SCHEMBL10847224 | 0.73 | HCN4 (0.79) | MAPTHCN4CYP3A4ALOX15DRD3 | |
| SCHEMBL5759813 | 0.72 | PDE4B (0.55) | MAPTHCN4CYP3A4ALOX15POLB | |
| Hydrochloric Acid SCHEMBL11018724 | 0.72 | CYP3A4 (0.79) | MAPTHCN4CYP3A4ALOX15DRD3 | |
| SCHEMBL4874264 | 0.71 | POLB (0.41) | POLBPGK1L3MBTL1 | |
| SCHEMBL12856192 | 0.69 | SIGMAR1 (0.56) | — | |
| SCHEMBL15760679 | 0.69 | TUBB4A (0.53) | CYP3A4POLB | |
| SCHEMBL12020315 | 0.68 | SKP2 (0.53) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090081-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |