Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983534 | 0.81 | MAPT (0.44) | L3MBTL1 | |
| SCHEMBL10504904 | 0.80 | KMT2A (0.48) | KCNH2RAB9AHRH3L3MBTL1ADRA1A | |
| SCHEMBL4875539 | 0.79 | ADAMTS5 (0.40) | RAB9AL3MBTL1ADRA1AADRA1B | |
| SCHEMBL4865427 | 0.78 | ADAMTS5 (0.39) | SIGMAR1RAB9AHRH3L3MBTL1ADRA1A | |
| SCHEMBL6986641 | 0.74 | EPHX2 (0.38) | SIGMAR1L3MBTL1 | |
| SCHEMBL4875116 | 0.73 | ADAMTS5 (0.43) | KCNH2SIGMAR1HRH3L3MBTL1 | |
| SCHEMBL11131212 | 0.72 | KCNH2 (0.84) | KCNH2 | |
| SCHEMBL3733154 | 0.71 | ALOX5 (0.45) | RAB9AL3MBTL1CHRM1ADRA1AADRA1B | |
| SCHEMBL7222562 | 0.70 | ADRA1B (0.41) | RAB9AL3MBTL1CHRM1ADRA1AADRA1B | |
| SCHEMBL24072918 | 0.70 | ALOX5 (0.47) | RAB9AL3MBTL1ADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090081-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |