Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | HRH2 | P25021 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 4/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976685 | 0.96 | KCNH2 (0.38) | KCNH2HRH2HTR6 | |
| SCHEMBL6981562 | 0.78 | DRD2 (0.43) | DRD2 | |
| SCHEMBL6981384 | 0.78 | DRD2 (0.43) | DRD2 | |
| SCHEMBL7811043 | 0.78 | DRD2 (0.43) | DRD2 | |
| Oxalic Acid SCHEMBL8311341 | 0.78 | HTR2A (0.46) | KCNH2DRD2 | |
| Hydrochloric Acid SCHEMBL6985847 | 0.77 | DRD2 (0.42) | DRD2 | |
| Hydrochloric Acid SCHEMBL7811763 | 0.77 | DRD2 (0.42) | DRD2 | |
| Bromide SCHEMBL7811682 | 0.77 | DRD2 (0.42) | DRD2 | |
| Bromide SCHEMBL7811677 | 0.77 | DRD2 (0.42) | DRD2 | |
| Hydrochloric Acid SCHEMBL6984757 | 0.77 | DRD2 (0.42) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923575-B1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-6172085-B1 | CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-0923575-A1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | Takeda Chemical Industries, Ltd. (JP) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998008842-A1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-05 | — | — | WO | disclosed |