Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980629 | 0.95 | APP (0.41) | OPRM1ABCB11LMNAMAPTMAPK1 | |
| SCHEMBL6975621 | 0.87 | APP (0.38) | OPRM1ABCB11LMNAMAPTMAPK1 | |
| SCHEMBL6976227 | 0.80 | ALDH1A1 (0.35) | ABCB11LMNAMAPTMAPK1TSHR | |
| SCHEMBL6979573 | 0.78 | OPRM1 (0.49) | OPRM1ABCB11LMNAMAPTMAPK1 | |
| SCHEMBL6981407 | 0.77 | CNR1 (0.37) | MAPK1ALDH1A1 | |
| SCHEMBL6971194 | 0.74 | OPRM1 (0.45) | OPRM1ABCB11LMNAMAPTMAPK1 | |
| SCHEMBL6970913 | 0.74 | OPRM1 (0.45) | OPRM1ABCB11LMNAMAPTMAPK1 | |
| SCHEMBL6983251 | 0.73 | GAA (0.47) | OPRM1ABCB11LMNAMAPTMAPK1 | |
| SCHEMBL11204901 | 0.73 | POLB (0.43) | ABCB11LMNAMAPTMAPK1MEN1 | |
| SCHEMBL11202315 | 0.69 | MAPT (0.45) | ABCB11LMNAMAPTMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | claimed |