Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 6/20 | 0.48 |
| ▸ | CCND1 | P24385 | 6/20 | 0.48 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.48 |
| ▸ | CDK2 | P24941 | 5/20 | 0.48 |
| ▸ | PRKACA | P17612 | 4/20 | 0.48 |
| ▸ | PRKACG | P22612 | 4/20 | 0.48 |
| ▸ | PRKACB | P22694 | 4/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.47 |
| ▸ | CDK9 | P50750 | 3/20 | 0.47 |
| ▸ | PIM1 | P11309 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983267 | 0.87 | CCNE2 (0.45) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6980064 | 0.86 | PRKACA (0.52) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7835441 | 0.85 | PRKACA (0.44) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6982388 | 0.85 | PRKACA (0.56) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6981937 | 0.85 | CAMK2D (0.56) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6979319 | 0.84 | CAMK2D (0.52) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6982705 | 0.82 | PRKACA (0.41) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6979903 | 0.81 | CCNT1 (0.45) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6982166 | 0.80 | PRKCB (0.51) | CDK4CCND1CCNE2CCNE1CDK2 | |
| Trifluoroacetic Acid SCHEMBL6986094 | 0.80 | PRKACA (0.45) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | claimed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | claimed |
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |