Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.51 |
| ▸ | RELA | Q04206 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27816724 | 0.87 | RAB9A (0.56) | RIPK1TP53SMN1; SMN2NPC1RAB9A | |
| Thidiazuron SCHEMBL1808496 | 0.79 | SMN1; SMN2 (0.57) | TP53SMN1; SMN2MAPTNPC1RAB9A | |
| Thidiazuron SCHEMBL121077 | 0.79 | SMN1; SMN2 (0.57) | TP53SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL11282790 | 0.79 | — | — | |
| Thidiazuron SCHEMBL20723866 | 0.78 | SMN1; SMN2 (0.55) | TP53SMN1; SMN2MAPTNPC1RAB9A | |
| Thidiazuron SCHEMBL15553871 | 0.78 | SMN1; SMN2 (0.55) | TP53SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL11336495 | 0.77 | CCNE1 (0.47) | RIPK1TP53SMN1; SMN2MAPTNPC1 | |
| SCHEMBL10980189 | 0.76 | BAZ1A (0.50) | RIPK1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL8374462 | 0.74 | SMN1; SMN2 (0.49) | RIPK1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL11393556 | 0.74 | RIPK1 (0.41) | RIPK1SMN1; SMN2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288556-B2 | Antiproliferative 1,2,3-thiadiazole compounds | QLT INC. (CA) | 2007-10-30 | — | — | US | disclosed |
| EP-1353915-A2 | THERAPEUTIC CHROMAN COMPOUNDS | AstraZeneca AB (SE) | 2003-10-22 | — | — | EP | disclosed |
| EP-1353914-A2 | THERAPEUTIC CHROMONE COMPOUNDS | AstraZeneca AB (SE) | 2003-10-22 | — | — | EP | disclosed |
| EP-1353913-A2 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | AstraZeneca AB (SE) | 2003-10-22 | — | — | EP | disclosed |
| WO-2002055012-A2 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | ASTRAZENECA AB (SE) | 2002-07-18 | — | — | WO | disclosed |
| WO-2002055013-A2 | THERAPEUTIC CHROMONE COMPOUNDS | ASTRAZENECA AB (SE) | 2002-07-18 | — | — | WO | disclosed |
| WO-2002055014-A2 | THERAPEUTIC CHROMAN COMPOUNDS | ASTRAZENECA AB (SE) | 2002-07-18 | — | — | WO | disclosed |
| US-3946000-A | BACTERICIDES, POULTRY, ANIMALS | BRISTOL-MYERS COMPANY (US) | 1976-03-23 | — | — | US | disclosed |