Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770708 | 0.88 | PTGDR2 (0.47) | MAPTLMNASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL7778630 | 0.85 | MAPT (0.66) | MAPTLMNASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL13623312 | 0.85 | PTGDR2 (0.44) | MAPTLMNASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL8770253 | 0.85 | S1PR4 (0.49) | MAPTLMNASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL12838161 | 0.85 | KMT2A (0.49) | MAPTSMN1; SMN2ALDH1A1RAB9AHPGD | |
| SCHEMBL3535207 | 0.83 | MAPT (0.60) | MAPTLMNASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL6814539 | 0.83 | PTPN7 (0.49) | MAPTLMNASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL17538570 | 0.82 | MAPT (0.65) | MAPTLMNASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL29028695 | 0.82 | MAPT (0.61) | MAPTLMNASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL2947864 | 0.81 | LMNA (0.45) | MAPTLMNASMN1; SMN2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030835-B1 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA UK LTD (GB) | 2003-01-22 | — | — | EP | disclosed |
| US-6344570-B1 | ANTISTICKING AGENTS FOR CELLS | ASTRAZENECA UK LIMITED (GB) | 2002-02-05 | — | — | US | disclosed |
| EP-1030835-A2 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | AstraZeneca UK Limited (GB) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999024398-A2 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |