Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 7/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6049274 | 0.83 | GABRA1 (0.40) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7217088 | 0.81 | PRKAB2 (0.36) | NR4A2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL6631032 | 0.79 | GABRA1 (0.48) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6648434 | 0.76 | GABRA1 (0.46) | GABRA1NR4A2CREBBPGABRB2PRKAB2 | |
| SCHEMBL22032169 | 0.75 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6991795 | 0.73 | NR4A2 (0.51) | NR4A2CREBBPLMNAMAPTNPSR1 | |
| SCHEMBL6699986 | 0.72 | NR4A2 (0.72) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL1007089 | 0.72 | NR4A2 (0.50) | NR4A2CREBBPLMNARAB9AMEN1 | |
| SCHEMBL6986880 | 0.72 | NR4A2 (0.72) | GABRA1GABRA3NR4A2CREBBPGABRB1 | |
| SCHEMBL15557355 | 0.72 | KDM4E (0.54) | GABRA1GABRG2GABRB3GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349833-A1 | INDOLE AND DIHYDROINDOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002044149-A1 | INDOLE AND DIHYDROINDOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-06 | — | — | WO | disclosed |