SCHEMBL6984175

SCHEMBL6984175

CC1CCNc2ccc([N+](=O)[O-])cc21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB4 P30926 2/20 0.43
CHRNA3 P32297 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
ALDH1A1 P00352 2/20 0.43
HSP90AA1 P07900 1/20 0.42
PNMT P11086 3/20 0.41
ADRA2A P08913 1/20 0.41
ADRA2B P18089 1/20 0.41
ADRA2C P18825 1/20 0.41
CHRNA7 P36544 1/20 0.41
NPC1 O15118 1/20 0.40
MAPT P10636 1/20 0.40
RAB9A P51151 1/20 0.40
AR P10275 1/20 0.39
PGR P06401 1/20 0.39
GAA P10253 1/20 0.39
GAPDH P04406 1/20 0.39
HSPA1A P0DMV8 1/20 0.39
HSPA8 P11142 1/20 0.39
CD44 P16070 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6647761 0.88 SMN1; SMN2 (0.44) CHRNB4CHRNA3SMN1; SMN2ALDH1A1HSP90AA1
SCHEMBL12813209 0.84 CHRNB4 (0.49) CHRNB4CHRNA3SMN1; SMN2ALDH1A1HSP90AA1
SCHEMBL1347263 0.78 CRBN (0.46) CHRNB4CHRNA3SMN1; SMN2ALDH1A1CHRNA7
SCHEMBL10869497 0.78 HSP90AA1 (0.40) CHRNB4CHRNA3SMN1; SMN2ALDH1A1HSP90AA1
SCHEMBL11269752 0.77 NPC1 (0.40) CHRNB4CHRNA3SMN1; SMN2ALDH1A1HSP90AA1
SCHEMBL17479578 0.75 ALDH1A1 (0.51) CHRNB4CHRNA3SMN1; SMN2ALDH1A1PNMT
SCHEMBL30100756 0.75 ALDH1A1 (0.51) CHRNB4CHRNA3SMN1; SMN2ALDH1A1PNMT
SCHEMBL5537547 0.74 AR (0.40) SMN1; SMN2ALDH1A1MAPTARPGR
SCHEMBL24982 0.73 MAPT (0.49) ALDH1A1PNMTADRA2ANPC1MAPT
SCHEMBL8312203 0.73 ALDH1A1 (0.50) CHRNB4CHRNA3SMN1; SMN2ALDH1A1HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0991624-B1 PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT BOEHRINGER INGELHEIM PHARMA (DE) 2003-11-19 EP disclosed
US-6300342-B1 FOR THERAPY OR INHIBITING THROMBUS FORMATION; FOR THERAPY OF FIBRIN-DEPENDENT INFLAMMATORY CONDITION BOEHRINGER INGELHEIM PHARM KG (DE) 2001-10-09 US disclosed