Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7893289 | 0.76 | KDM4E (0.39) | KDM4ENPC1LTB4RLTB4R2SMN1; SMN2 | |
| SCHEMBL7893294 | 0.75 | ALDH1A1 (0.38) | KDM4ELTB4RLTB4R2SMN1; SMN2GLS | |
| SCHEMBL28953834 | 0.72 | HPGD (0.43) | NPC1SLC18A3SMN1; SMN2GLSHPGD | |
| SCHEMBL29950596 | 0.72 | HPGD (0.43) | NPC1SLC18A3SMN1; SMN2GLSHPGD | |
| SCHEMBL8094726 | 0.71 | HRH3 (0.43) | LTB4RLTB4R2SMN1; SMN2KDM1AMAOA | |
| SCHEMBL8091807 | 0.71 | HRH3 (0.43) | LTB4RLTB4R2SMN1; SMN2KDM1AMAOA | |
| SCHEMBL16269835 | 0.71 | HRH3 (0.43) | LTB4RLTB4R2SMN1; SMN2KDM1AMAOA | |
| SCHEMBL3423813 | 0.70 | HRH3 (0.38) | KDM4ENPC1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1515445 | 0.68 | SMN1; SMN2 (0.48) | KDM4ESMN1; SMN2GLSMAOAMAOB | |
| SCHEMBL11541050 | 0.68 | CYP19A1 (0.40) | LTB4RLTB4R2SMN1; SMN2CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189902-B1 | 7-OXO-2-AZABICYCLO[2.2.1]HEPTANES AS SELECTIVE MUSCARINIC RECEPTOR ANTAGONIST | LILLY CO ELI (US) | 2003-08-27 | — | — | EP | claimed |
| EP-1189902-B1 | 7-OXO-2-AZABICYCLO[2.2.1]HEPTANES AS SELECTIVE MUSCARINIC RECEPTOR ANTAGONIST | LILLY CO ELI (US) | 2003-08-27 | — | — | EP | disclosed |
| US-6559171-B1 | Muscarinic receptor modulators 7-oxo-2-azabicyclo(2.2.1)heptanes of formula (I) which are useful for the treatment of various diseases and conditions, for example, Alzheimer's disease, glaucoma, psychosis, | ELI LILLY AND COMPANY | 2003-05-06 | — | — | US | disclosed |