Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984252 | 0.75 | KDM4E (0.40) | ALDH1A1KDM4ELTB4RLTB4R2GLS | |
| SCHEMBL7893260 | 0.74 | ALDH1A1 (0.40) | ALDH1A1KDM4EP2RX7HSD11B1GLS | |
| SCHEMBL7893289 | 0.74 | KDM4E (0.39) | ALDH1A1KDM4EP2RX7HSD11B1LTB4R | |
| SCHEMBL28953834 | 0.73 | HPGD (0.43) | GLSSMN1; SMN2 | |
| SCHEMBL29950596 | 0.73 | HPGD (0.43) | GLSSMN1; SMN2 | |
| SCHEMBL11541056 | 0.72 | CYP19A1 (0.40) | LTB4RLTB4R2CHRM2CHRM4CHRM5 | |
| SCHEMBL11541050 | 0.72 | CYP19A1 (0.40) | LTB4RLTB4R2CHRM2CHRM4CHRM5 | |
| SCHEMBL11541062 | 0.72 | CYP19A1 (0.40) | LTB4RLTB4R2CHRM2CHRM4CHRM5 | |
| SCHEMBL8091807 | 0.72 | HRH3 (0.43) | ALDH1A1LTB4RLTB4R2KDM1AMAOA | |
| SCHEMBL16269835 | 0.72 | HRH3 (0.43) | ALDH1A1LTB4RLTB4R2KDM1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900204-A4 | HETEROCYCLIC COMPOUNDS | LILLY CO ELI (US) | 2001-03-21 | — | — | EP | disclosed |
| US-6124312-A | ACTIVE DRUG FOR TREATING ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 2000-09-26 | — | — | US | disclosed |
| EP-0900204-A1 | HETEROCYCLIC COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-03-10 | — | — | EP | disclosed |
| WO-1997040016-A1 | HETEROCYCLIC COMPOUNDS | ELI LILLY AND COMPANY (US) | 1997-10-30 | — | — | WO | disclosed |