SCHEMBL6984267

SCHEMBL6984267

COc1ccc(C(NC2CCN(CC3(C)Cc4c(C)c(N)c(C)c(C)c4O3)CC2)c2ccc(OC)cc2)cc1

nearest known ligand 0.31

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CXCR3 P49682 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
MCHR1 Q99705 1/20 0.30
HRH3 Q9Y5N1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6978239 0.89 SLC6A4 (0.37)
SCHEMBL6983686 0.89 CHRM1 (0.32)
SCHEMBL6980124 0.89 CHRM1 (0.32)
SCHEMBL6976347 0.89 CHRM1 (0.32)
Hydrochloric Acid SCHEMBL6980788 0.88 CHRM1 (0.31)
Sulfuric Acid SCHEMBL6985648 0.84 MGLL (0.31)
Sulfuric Acid SCHEMBL6984280 0.84 MGLL (0.31)
Sulfuric Acid SCHEMBL6984275 0.84 MGLL (0.31)
SCHEMBL9396587 0.83 DRD2 (0.47)
SCHEMBL6977637 0.81 CHRM1 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923575-B1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-03-12 EP disclosed
US-6172085-B1 CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-01-09 US disclosed